http://www.ncbi.nlm.nih.gov/pubmed/18458765?dopt=AbstractPlus
(08/05/08)
Prim Care Companion J Clin Psychiatry. 2008;10(2):120-8.
A Systematic Review of Chronic Fatigue Syndrome: DON'T ASSUME IT'S DEPRESSION.Griffith JP, Zarrouf FA.
Internal Medicine/Psychiatry Residency Program, West Virginia
University, Charleston.
Objective: Chronic fatigue syndrome (CFS) is characterized by profound,
debilitating fatigue and a combination of several other symptoms
resulting in substantial reduction in occupational, personal, social,
and educational status. CFS is often misdiagnosed as depression. The
objective of this study was to evaluate and discuss different
etiologies, approaches, and management strategies of CFS and to present
ways to differentiate it from the fatigue symptom of depression.
Data Sources: A MEDLINE search was conducted to identify existing
information about CFS and depression using the headings chronic fatigue
syndrome AND depression. The alternative terms major depressive disorder
and mood disorder were also searched in conjunction with the term
chronic fatigue syndrome. Additionally, MEDLINE was searched using the
term chronic fatigue. All searches were limited to articles published
within the last 10 years, in English. A total of 302 articles were
identified by these searches. Also, the term chronic fatigue syndrome
was searched by itself. This search was limited to articles published
within the last 5 years, in English, and resulted in an additional 460
articles. Additional publications were identified by manually searching
the reference lists of the articles from both searches.
Study Selection
and Data Extraction: CFS definitions, etiologies, differential diagnoses
(especially depression) and management strategies were extracted,
reviewed, and summarized to meet the objectives of this article.
Data Synthesis: CFS is underdiagnosed in more than 80% of the people who
have it; at the same time, it is often misdiagnosed as depression.
Genetic, immunologic, infectious, metabolic, and neurologic etiologies
were suggested to explain CFS. A biopsychosocial model was suggested for
evaluating, managing, and differentiating CFS from depression.
Conclusions: Evaluating and managing chronic fatigue is a
challenging situation for physicians, as it is a challenging and
difficult condition for patients. A biopsychosocial approach in the
evaluation and management is recommended. More studies about CFS
manifestations, evaluation, and management are needed.
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The full text of
"A Systematic Review of Chronic Fatigue Syndrome: Don't Assume It's Depression"
Journal: Prim Care Companion J Clin Psychiatry. 2008;10(2):120-8.
Authors: Griffith JP, Zarrouf FA.
is currently available for free at
http://psychiatrist.com/pcc/pccpdf/v10n02/v10n0206.pdf
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