Link between fibro and brain chemical

Source: Medical News Today
Date:   March 11, 2008
Author: Katie Vloet
URL:    http://www.medicalnewstoday.com/articles/100214.php


Fibromyalgia pain and changes in brain molecule linked
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Researchers at the University of Michigan Health System have found a key linkage
between pain and a specific brain molecule, a discovery that lends new insight
into fibromyalgia, an often-baffling chronic pain condition.

In patients with fibromyalgia, researchers found, pain decreased when levels of
the brain molecule called glutamate went down. The results of this study, which
appears in the journal Arthritis and Rheumatism, could be useful to researchers
looking for new drugs that treat fibromyalgia, the authors say.

"If these findings are replicated, investigators performing clinical treatment
trials in fibromyalgia could potentially use glutamate as a 'surrogate' marker
of disease response," says lead author Richard E. Harris, Ph.D., research
assistant professor in the Division of Rheumatology at the U-M Medical School's
Department of Internal Medicine and a researcher at the U-M Chronic Pain and
Fatigue Research Center.

The molecule glutamate is a neurotransmitter, which means it conveys information
between neurons in the nervous system. When glutamate is released from one
neuron, it diffuses across the space between cells, and then binds to receptors
on the next neuron in line and causes the cell to become excited, or to be more
active.

This molecule was suspected to play a role in fibromyalgia because previous
studies had shown that some brain regions in fibromyalgia patients appear to be
highly excited. One such region is the insula.

In functional magnetic resonance imaging (fMRI) studies, researchers at U-M had
previously shown that the insula displays augmented activity in fibromyalgia,
which means neurons in these patients are more active in this part of the brain.
The U-M team hypothesized, Harris notes, that more activity among these neurons
might be related to the level of glutamate in this region.

To gauge the linkage between pain and glutamate, the researchers used a non-
invasive brain imaging techinique called proton magnetic resonance spectroscopy
(H-MRS). H-MRS was performed once before and once following a four-week course
of acupuncture or "sham" acupuncture.

Researchers used either acupuncture or sham acupuncture to reduce pain symptoms.
The sham procedure involved using a sharp device to prick the skin in order to
mimic real acupuncture sensations.

Following the four weeks of treatment, both clinical and experimental pain
reported were reduced significantly. More importantly the reduction in both pain
outcomes was linked with reductions in glutamate levels in the insula: patients
with greater reductions in pain showed greater reductions in glutamate. This
suggests that glutamate may play a role in this disease and that it could
potentially be used as a biomarker of disease severity.

Because of the small number of participants in this study, further research
should be conducted to verify the role of glutamate in fibromyalgia, Harris
says.


The senior author of the study was Daniel J. Clauw, M.D., director of the U-M
Chronic Pain and Fatigue Research Center. Other authors were Richard H. Gracely,
Ph.D., and Seong-Ho Kim, M.D., of the U-M Department of Internal Medicine; Pia
C. Sundgren, M.D., Ph.D., Yuxi Pang, Ph.D., and Myria Petrou, M.D., of the U-M
Department of Radiology; Michael Hsu, M.D., of the U-M Department of Physical
Medicine and Rehabilitation; and Samuel A. McLean, M.D., of the U-M Department
of Emergency Medicine.

Funding came from a Department of Army grant, the National Institutes of Health,
and the NIH National Center for Complementary and Alternative Medicine.

Reference: Arthritis and Rheumatism, March 2008, Volume 58, Issue 3, "Dynamic
Levels of Glutamate within the Insula are Associated with Improvements in
Multiple Pain Domains in Fibromyalgia."

U-M Chronic Fibromyalgias site,
   http://www.med.umich.edu/painresearch/patients/fibromyalgia.htm

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(c) 2008 Medical News Today