Neurobiological Differences Found in CFS

A study of neurochemicals in the brain and cerebrospinal fluid is shedding light on neurometabolic activity in CFS and how it differs from neuropsychiatric disorders that have symptoms that overlap CFS.
See http://www.cfids.org/cfidslink/2007/neurobiological.asp

Just because illnesses have similar symptoms doesn't mean that they are the same illness. CFS shares symptoms with MS, AIDS, cancer, thyroid, polio... but isn't any of them.
The latest information on what CFS is (not the assumptions that it "might be" psychosomatic, but the truth) is at See http://www.cfids.org/cfidslink/2007/iacfs.asp, the report on the latest IACFS conference.
There was "a convergence of findings" around brain function and traits, mitochondrial dysfunction and oxidative stress, molecular biomarkers, virology and epidemiology.
For example, brain imaging and cognitive testing, exercise testing, genomic analysis, spinal fluid protein and cardio monitoring have all uncovered indications of oxidative stress and/or mitochondrial dysfunction in CFS. The mitochondria are involved in energy conversion at the cellular level.

However, as Dr. Starlanyl has stressed, "all tests are normal may mean the proper tests have not been done". Doing the correct tests may show something very different.
Nearly a quarter-century after the Tahoe epidemic, there are still doctors who don't know the first thing about CFS and are convinced that it's fakery because the basic blood tests are normal. Most of them refuse to be educated.
If you run into a doctor who refuses to accept that your problem is not psychological and comes up with the most far-fetched explanation for what you're really depressed/anxious over, change doctors!
I made the mistake of believing that because it was a well-respected medical group, they knew what they were doing. All they really knew how to do was to string me along until it was too late. Too late to recuperate and too late to sue.
If you get proper treatment in the early stages, your chances of remission are good. The longer it takes to get help, the worse your odds. After 5 years, the odds are almost nil, and, unfortunately, it took 5 years for me to get to someone who knew what he was doing.
Not every doctor knows everything about every disease. Do yourself a favor and find someone who DOES know about CFS. They'll deride this as "doctor shopping", but regaining your health is more important than paying attention to verbal abuse.